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In most cases, the elimination of nicotine in mammals is via conversion to cotinine by C-oxidation

In this minority context, enslaved Africans and African Americans had less access to the extended kinship connections found with large enslaved communities in black majority contexts

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Researchers found evidence of reduced motivation in adolescent cannabis users, and that those who used cannabis early demonstrated poorer performance on tasks of sustained attention, impulse control, and executive functioning. Researchers also found that subjects who started using cannabis before the age of 15 showed significant impairment in reaction times, whereas users who abstained until after the age of 15 were not affected